Cytotoxicity and Hemostatic One Step Green Synthesis of Iron Nanoparticles Coated with Green Tea for Biomedical Application

Heparin and its low molecular weight are anticoagulants that prevent the formation extension of blood clots. However, these anticoagulant causes bleeding takes longer to stop. Here, we explore using magnetic iron oxide (Fe3O4NPs) coated with green tea (GTPs) as a safe effective nontherapeutic agent for clotting prevention. In this work, Magnetic (GT@Fe3O4NPs) was successfully synthesized simple eco-friendly method. Green is employed reducing stabilizing agent. We method new low-cost time-consuming route. Structural, biocompatibility properties were analyzed. These analyses showed particles uniform shapes sizes 25 - 36 nm coating GTPs. The vibrating sample magnetometer (VSM) measurement demonstrated saturation magnetization 4.90 emu/g negligible coercivity retentivity, indicating superparamagnetic behavior GT@Fe3O4NPs at room temperature. nanoparticles highly stable well-dispersed in an aqueous medium through their hydrophilic Cell viability prothrombin time (PT) excellent compatibility addition promising ability, respectively. work offers novel, nanotherapeutic substitutional heparin. As result, can compete heparin either hemodialysis or treatment thromboembolic events it overcome related problems great extent. HIGHLIGHTS (Fe3O4 NPs) could be heparin, overcoming side effects such advance drugs by increasing control (e.g., decreasing dose while maintaining efficacy circulation) will profit patients undergoing high-risk surgical procedures anticoagulant-related extent GRAPHICAL ABSTRACT